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GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension.
Toyama T, Kudryashova TV, Ichihara A, Lenna S, Looney A, Shen Y, Jiang L, Teos L, Avolio T, Lin D, Kaplan U, Marden G, Dambal V, Goncharov D, Delisser H, Lafyatis R, Seta F, Goncharova EA, Trojanowska M. Toyama T, et al. Sci Rep. 2023 Apr 22;13(1):6593. doi: 10.1038/s41598-023-33779-8. Sci Rep. 2023. PMID: 37087509 Free PMC article.
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and often death. Here we report that deficiency of transcription factor GATA6 is a shared pat …
Pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by a progressive increase in pulmonary vascular resistan …
BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance.
Capasso TL, Li B, Volek HJ, Khalid W, Rochon ER, Anbalagan A, Herdman C, Yost HJ, Villanueva FS, Kim K, Roman BL. Capasso TL, et al. Angiogenesis. 2020 May;23(2):203-220. doi: 10.1007/s10456-019-09701-0. Epub 2019 Dec 11. Angiogenesis. 2020. PMID: 31828546 Free PMC article.
In contrast, combined loss of bmp10 and bmp10-like results in embryonic lethal cranial AVMs indistinguishable from acvrl1 mutants. However, despite embryonic functional redundancy of bmp10 and bmp10-like, bmp10 encodes the only required Alk1 lig …
In contrast, combined loss of bmp10 and bmp10-like results in embryonic lethal cranial AVMs indistinguishable from acvrl1 muta …
An angiopoietin 2, FGF23, and BMP10 biomarker signature differentiates atrial fibrillation from other concomitant cardiovascular conditions.
Chua W, Cardoso VR, Guasch E, Sinner MF, Al-Taie C, Brady P, Casadei B, Crijns HJGM, Dudink EAMP, Hatem SN, Kääb S, Kastner P, Mont L, Nehaj F, Purmah Y, Reyat JS, Schotten U, Sommerfeld LC, Zeemering S, Ziegler A, Gkoutos GV, Kirchhof P, Fabritz L. Chua W, et al. Sci Rep. 2023 Oct 5;13(1):16743. doi: 10.1038/s41598-023-42331-7. Sci Rep. 2023. PMID: 37798357 Free PMC article.
Early detection of atrial fibrillation (AF) enables initiation of anticoagulation and early rhythm control therapy to reduce stroke, cardiovascular death, and heart failure. In a cross-sectional, observational study, we aimed to identify a combination of circulating biomol …
Early detection of atrial fibrillation (AF) enables initiation of anticoagulation and early rhythm control therapy to reduce stroke, cardiov …
FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells.
Quist-Løkken I, Andersson-Rusch C, Kastnes MH, Kolos JM, Jatzlau J, Hella H, Olsen OE, Sundan A, Knaus P, Hausch F, Holien T. Quist-Løkken I, et al. Cell Commun Signal. 2023 Jan 30;21(1):25. doi: 10.1186/s12964-022-01033-9. Cell Commun Signal. 2023. PMID: 36717825 Free PMC article.
Ligands that typically signal via ALK3 in myeloma cells, BMP2, BMP4, and BMP10, did not induce apoptosis in cells lacking ALK3. Notably, BMP10 competed with BMP6 and BMP9 and antagonized their activity via ALK2. ...This gain of activity was also seen in other cell t …
Ligands that typically signal via ALK3 in myeloma cells, BMP2, BMP4, and BMP10, did not induce apoptosis in cells lacking ALK3. Notab …
Myocardin regulates BMP10 expression and is required for heart development.
Huang J, Elicker J, Bowens N, Liu X, Cheng L, Cappola TP, Zhu X, Parmacek MS. Huang J, et al. J Clin Invest. 2012 Oct;122(10):3678-91. doi: 10.1172/JCI63635. Epub 2012 Sep 17. J Clin Invest. 2012. PMID: 22996691 Free PMC article.
Cardiac hypoplasia was caused by decreased cardiomyocyte proliferation accompanied by a dramatic increase in programmed cell death. Defective chamber maturation and the block in cardiomyocyte proliferation were caused in part by a block in BMP10 signaling. Myocardin …
Cardiac hypoplasia was caused by decreased cardiomyocyte proliferation accompanied by a dramatic increase in programmed cell death. D …
BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways.
Qu X, Liu Y, Cao D, Chen J, Liu Z, Ji H, Chen Y, Zhang W, Zhu P, Xiao D, Li X, Shou W, Chen H. Qu X, et al. J Biol Chem. 2019 Dec 27;294(52):19877-19888. doi: 10.1074/jbc.RA119.010943. Epub 2019 Nov 11. J Biol Chem. 2019. PMID: 31712309 Free PMC article.
We further confirmed this cardioprotective function with a newly generated conditional Bmp10 transgenic mouse line, in which Bmp10 was activated in adult hearts by tamoxifen. Moreover, the intraperitoneal administration of recombinant human BMP10 was found to …
We further confirmed this cardioprotective function with a newly generated conditional Bmp10 transgenic mouse line, in which Bmp10 …
Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation.
Hijazi Z, Benz AP, Lindbäck J, Alexander JH, Connolly SJ, Eikelboom JW, Granger CB, Kastner P, Lopes RD, Ziegler A, Oldgren J, Siegbahn A, Wallentin L. Hijazi Z, et al. Eur Heart J. 2023 Jan 14;44(3):208-218. doi: 10.1093/eurheartj/ehac632. Eur Heart J. 2023. PMID: 36380569 Free PMC article.
BMP10 was not independently associated with bleeding or with death. ...BMP10 seems to be more specifically related to the risk of ischaemic stroke in AF. ...
BMP10 was not independently associated with bleeding or with death. ...BMP10 seems to be more specifically related to t …
Bone Morphogenetic Protein 10-A Novel Biomarker to Predict Adverse Outcomes in Patients With Atrial Fibrillation.
Hennings E, Blum S, Aeschbacher S, Coslovsky M, Knecht S, Eken C, Lischer M, Paladini RE, Krisai P, Reichlin T, Rodondi N, Beer JH, Ammann P, Conte G, De Perna ML, Kobza R, Blum MR, Bossard M, Kastner P, Ziegler A, Müller C, Bonati LH, Pfister O, Zuern CS, Conen D, Kühne M, Osswald S; Swiss‐AF Investigators. Hennings E, et al. J Am Heart Assoc. 2023 Mar 21;12(6):e028255. doi: 10.1161/JAHA.122.028255. Epub 2023 Mar 16. J Am Heart Assoc. 2023. PMID: 36926939 Free PMC article.
For all-cause death, the concordance index was 0.783 (95% CI, 0.763-0.809) for BMP10, 0.784 (95% CI, 0.765-0.810) for NT-proBNP, and 0.789 (95% CI, 0.771-0.815) for both biomarkers combined. ...Conclusions BMP10 strongly predicted all-cause death and M …
For all-cause death, the concordance index was 0.783 (95% CI, 0.763-0.809) for BMP10, 0.784 (95% CI, 0.765-0.810) for NT-proBN …
Nkx2-5 Regulates the Proliferation and Migration of H9c2 Cells.
Wang H, Liu Y, Han S, Zi Y, Zhang Y, Kong R, Liu Z, Cai Z, Zhong C, Liu W, Li L, Jiang L. Wang H, et al. Med Sci Monit. 2020 Aug 11;26:e925388. doi: 10.12659/MSM.925388. Med Sci Monit. 2020. PMID: 32780729 Free PMC article.
In mice, the disruption of Nkx2-5 has been associated with arrhythmias, abnormal myocardial contraction, abnormal cardiac morphogenesis, and death. However, the details of the mechanisms are unclear. This study was designed to investigate them. ...CONCLUSIONS Nkx2-5 may re …
In mice, the disruption of Nkx2-5 has been associated with arrhythmias, abnormal myocardial contraction, abnormal cardiac morphogenesis, and …
Familial Left Ventricular Non-Compaction Is Associated With a Rare p.V407I Variant in Bone Morphogenetic Protein 10.
Hirono K, Saito K, Munkhsaikhan U, Xu F, Wang C, Lu L, Ichida F, Towbin JA, Purevjav E. Hirono K, et al. Circ J. 2019 Jul 25;83(8):1737-1746. doi: 10.1253/circj.CJ-19-0116. Epub 2019 Jun 26. Circ J. 2019. PMID: 31243186 Free article.
Although dimerization of mutant V407I-BMP10 was preserved like WT-BMP10, V407I-BMP10 pulled BMPR1a and BMPR2 receptors more weakly compared with WT-BMP10. ...Cyclic stretch resulted in destruction and death of V407I-BMP10 cells. CONCLUSIO …
Although dimerization of mutant V407I-BMP10 was preserved like WT-BMP10, V407I-BMP10 pulled BMPR1a and BMPR2 receptors …
18 results